Hydrochloric Acid → 2-Amino-5-isopropylthiazole-4-carboxylic acid

HRID 244662Notes

Reaction equation

HRID 244662 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:7]([O:9]C)=[O:8])[N:6]=1.Cl>O1CCOCC1>[NH2:1][C:2]1[S:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 737584Methyl 2-amino-5-(propan-2-yl)-1,3-thiazole-4-carboxylate

Product 1

HCID 100582492-Amino-5-isopropylthiazole-4-carboxylic acidYield 117.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of methyl 2-amino-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (220 mg) (for example, available from ABCR) in 1,4-dioxane (5 ml) was added 2M hydrochloric acid (5 ml) and the mixture heated at 110° C. for 72 h. The mixture was evaporated in vacuo to give the title compound (240 mg) as a pale yellow solid.

Workup

  1. customThe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-75d90a6cef4a4fc39f866710bd04e50c
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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