6-(4-Fluorophenyl)-1,3-dihydro-2H-indol-2-one → 3-{2-[6-(4-Fluorophenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-5-methyl-1H-pyrrol-3-yl}propionic Acid

HRID 24468Notes

Reaction equation

HRID 24468 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][C:13](=[O:17])[NH:14]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH:18]([C:20]1[NH:21][C:22]([CH3:30])=[CH:23][C:24]=1[CH2:25][CH2:26][C:27]([OH:29])=[O:28])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([C:12](=[CH:18][C:20]4[NH:21][C:22]([CH3:30])=[CH:23][C:24]=4[CH2:25][CH2:26][C:27]([OH:29])=[O:28])[C:13](=[O:17])[NH:14]3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 220421726-(4-Fluorophenyl)-1,3-dihydro-2H-indol-2-oneHCID 221353943-(2-Formyl-5-methyl-1H-pyrrol-3-yl)propanoic acid

Product 1

HCID 697638723-{2-[6-(4-Fluorophenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-5-methyl-1H-pyrrol-3-yl}propionic Acid

Procedure

6-(4-Fluorophenyl)-1,3-dihydroindol-2-one (70 mg, 0.31 mmol) was condensed with 3-(2-formyl-5-methyl-1H-pyrrol-3-yl)-propionic acid (56 mg) to give the title compound.

Sources & evidence

ORD record
ord-88c17c7d48db4061bbb4c4a807fa1b7c
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Reaction notes

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