反应详情

6-Bromo-1H-indazol-4-amine (5 g) was dissolved in DMF (20 ml) and cooled in an ice bath. 60% Sodium hydride in mineral oil (0.94 g) was added portionwise and the reaction was left under an ice bath for 30 min. Benzenesulfonyl chloride (3 ml) in DMF (5 ml) was added slowly over 15 minutes and the reaction was left to warm up to room temperature overnight. Water (100 ml) was added and the reaction stirred for 20 minutes. Ethyl acetate (120 ml) was added and the water was separated, washed with ethyl acetate (50 ml×2) and the combined organics were washed with 7.5% lithium chloride (aq) (50 ml×2) then water (50 ml) before being separated and passed through a hydrophobic frit. The ethyl acetate was evaporated and the residue passed through a silica cartridge, eluting with DCM (ca. 300 ml) followed by diethyl ether (ca. 400 ml). Product containing pure fractions were combined and evaporated to dryness to give title compound, 5.9 g.

1. temperaturecooled in an ice bath
2. waitthe reaction was left
3. customthe water was separated
4. washwashed with ethyl acetate (50 ml×2)
5. washthe combined organics were washed with 7.5% lithium chloride (aq) (50 ml×2)
6. customwater (50 ml) before being separated
7. customThe ethyl acetate was evaporated
8. washeluting with DCM (ca. 300 ml)
9. additionProduct containing pure fractions
10. customevaporated to dryness