HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-carbethoxy-4-(3-propionic acid)pyrrole → 4-(2-Carboxyethyl)-5-[6-(4-fluorophenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2-methyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-carbethoxy-4-(3-propionic acid)pyrrole | HCID 21728744 | — |
| Reactant | 6-(4-Fluorophenyl)-1,3-dihydro-2H-indol-2-one | HCID 22042172 | — |
| Reactant | 4-(2-carboxyethyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 54569391 | — |
| Product | 4-(2-Carboxyethyl)-5-[6-(4-fluorophenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2-methyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester | HCID 69764087 | — |
Reaction Steps
6-(4-Fluorophenyl)-1,3-dihydroindol-2-one (60 mg, 0.26 mmol) was condensed with 4-(2-carboxyethyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (65 mg), prepared by formylation of 4-(2-carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole (Bulter, A. R., and George, S. D. (1993) Tetrahedron 49: 7017-7026), to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855730B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-5cc4671342e249388623d4d7d8b97aa7 |
| Source note | uspto-grants-2005_02 |