Hydrazine hydrate (1:1) → 4-Iodo-1H-pyrazolo[3,4-b]pyridine

HRID 244692Notes

Reaction equation

HRID 244692 reaction equation
F[C:2]1[C:7]([CH:8]=O)=[C:6]([I:10])[CH:5]=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>O>[I:10][C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[NH:12][N:13]=[CH:8][C:7]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

Product 1

HCID 576428014-Iodo-1H-pyrazolo[3,4-b]pyridine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Fluoro-4-iodo-3-pyridinecarbaldehyde (from Asymchem) (0.97 g) was added portionwise over 5 min to hydrazine hydrate (5 ml). The resulting suspension was stirred at room temperature for 5 h. Water (10 ml) was added and the solid was filtered and washed with further water to give title compound, 664 mg.

Workup

  1. filtrationthe solid was filtered
  2. washwashed with further water

Sources & evidence

ORD record
ord-368915bb429a4681afba7d3f42f61558
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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