5-Chlorooxindole → 3-[2-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-5-methyl-1H-pyrrol-3-yl]propionic Acid

HRID 24471Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH:12]([C:14]1[NH:15][C:16]([CH3:24])=[CH:17][C:18]=1[CH2:19][CH2:20][C:21]([OH:23])=[O:22])=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:12][C:14]1[NH:15][C:16]([CH3:24])=[CH:17][C:18]=1[CH2:19][CH2:20][C:21]([OH:23])=[O:22]

Participants

Reactant 2

HCID 1528015-Chlorooxindole

HCID 221353943-(2-Formyl-5-methyl-1H-pyrrol-3-yl)propanoic acid

Product 1

HCID 541282473-[2-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-5-methyl-1H-pyrrol-3-yl]propionic Acid

Procedure

5-Chloro-1,3-dihydroindol-2-one (61 mg, 0.36 mmol) was condensed with 3-(2-formyl-5-methyl-1H-pyrrol-3-yl)-propionic acid (66 mg) to give the title compound.

Sources & evidence

ORD record: ord-496d5c51b6764accbaf764f51d64f2e1
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06855730B2

Reaction notes

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