N-[2-(benzyloxy)-5-(2-bromoacetyl)phenyl]methanesulfonamide → N-[2-Benzyloxy-5-[(2-ethyl-indan-2-ylamino)-acetyl]-phenyl]-methanesulfonamide

HRID 244805Notes

Reaction equation

HRID 244805 reaction equation
[CH2:1]([C:3]1([NH2:12])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1)[CH3:2].[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27](=[O:30])[CH2:28]Br)=[CH:23][C:22]=1[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(#N)C>[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27](=[O:30])[CH2:28][NH:12][C:3]2([CH2:1][CH3:2])[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4]2)=[CH:23][C:22]=1[NH:31][S:32]([CH3:35])(=[O:33])=[O:34])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 11200351N-[2-(benzyloxy)-5-(2-bromoacetyl)phenyl]methanesulfonamideHCID 224992562-ethyl-2,3-dihydro-1H-inden-2-amine

Product 1

HCID 22499207N-[2-Benzyloxy-5-[(2-ethyl-indan-2-ylamino)-acetyl]-phenyl]-methanesulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-ethyl-indan-2-ylamine and N-(2-benzyloxy-5-bromoacetyl-phenyl)-methanesulfonamide is stirred in acetonitrile at room temperature for 20 hours. The product is isolated by filtration. ES+ MS m/e 479 (MH+)

Workup

  1. customThe product is isolated by filtration

Sources & evidence

ORD record
ord-496149cb88364a15aaade637c5b159eb
Source dataset
uspto-grants-2014_02
Patent number
US08658673B2

Reaction notes

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