Methyl Acrylate → HCID 57657256, compound

HRID 244829Notes

Reaction equation

[NH2:1][C:2]1[C:11]2[N:12]=[CH:13][N:14]([CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])[C:10]=2[C:9]2[CH:8]=[C:7](Br)[CH:6]=[CH:5][C:4]=2[N:3]=1.[C:21]([O:25][CH3:26])(=[O:24])[CH:22]=[CH2:23]>>[NH2:1][C:2]1[C:11]2[N:12]=[CH:13][N:14]([CH2:15][C:16]([OH:18])([CH3:19])[CH3:17])[C:10]=2[C:9]2[CH:8]=[C:7](/[CH:23]=[CH:22]/[C:21]([O:25][CH3:26])=[O:24])[CH:6]=[CH:5][C:4]=2[N:3]=1

Participants

Reactant 2

HCID 7294Methyl Acrylate

HCID 69080714HCID 69080714, compound

Product 1

HCID 57657256HCID 57657256, compound

Procedure

The method described in Example 15 Part E can be used to couple 1-(4-amino-8-bromo-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol with methyl acrylate to provide Methyl(2E)-3-[4-amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-8-yl]prop-2-enoate.

Sources & evidence

ORD record: ord-e28683f3014c49b58e44189041b9422f
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08658666B2

Reaction notes

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