huagongshe.com
HRID244904

反应详情

EQUATION

反应方程式

HRID 244904 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)c1sc(C#CC(C)(C)C)cc1NC1CCC(n2cncn2)CC1
HCID24988981

未命名化合物

结构：C[C@H]1CC[C@H](C(=O)Cl)CC1
HCID178461265

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@H]1CC[C@H](C)CC1)C1CCC(n2cncn2)CC1
HCID178499329

未命名化合物

PROCEDURE

实验过程

5-(3,3-Dimethyl-but-1-ynyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)-thiophene-2-carboxylic acid methyl ester (0.27 g, 0.70 mmol) is acylated with trans-4-methylcyclohexyl carboxylic acid chloride as previously described to give 5-(3,3-dimethyl-but-1-ynyl)-3-[(trans-4-methyl-cyclohexanecarbonyl)-(4-[1,2,4]triazol-1-yl-cyclohexyl)-amino]-thiophene-2-carboxylic acid methyl ester.