Acetone Cyanohydrin → 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of p-toluidine (1.07 g, 10 mmol) and acetone cyanohydrin (10 ml) was heated to 80° C. and stirred for 4 h. The medium was concentrated and dried under vacuum to yield 2-methyl-2-(4-methylphenyl)aminopropanenitrile, 5a (1.72 g, 9.9 mmol, 99%) as brown solid.

Provenance & Evidence