Acetone Cyanohydrin → 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile

HRID 244969ノート

反応式

HRID 244969 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.[CH3:9][C:10]([CH3:14])(O)[C:11]#[N:12]>>[CH3:9][C:10]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1)([CH3:14])[C:11]#[N:12]

参加物

3

反応物 2

HCID 6406Acetone CyanohydrinHCID 7813p-Toluidine

生成物 1

HCID 212392432-Methyl-2-[(4-methylphenyl)amino]propanenitrile収率 99%

反応条件

温度
80 °C

実験手順

A mixture of p-toluidine (1.07 g, 10 mmol) and acetone cyanohydrin (10 ml) was heated to 80° C. and stirred for 4 h. The medium was concentrated and dried under vacuum to yield 2-methyl-2-(4-methylphenyl)aminopropanenitrile, 5a (1.72 g, 9.9 mmol, 99%) as brown solid.

後処理

  1. concentrationThe medium was concentrated
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-2c9e85e79b0847ab9dc519139d06e06d
出典データセット
uspto-grants-2014_02
特許番号
US08658681B2

反応ノート

読み込み中…