Hydrochloric Acid → Salcaprozate sodium

HRID 245044Notes

Reaction equation

HRID 245044 reaction equation
[Na].[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22].Cl>O>[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86585230HCID 86585230, compound

Product 1

HCID 23669833Salcaprozate sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Free acid of SNAC (i.e. N-(8-[2-hydroxybenzoyl]amino)caprylic acid) was prepared as follows. The monosodium SNAC prepared in Example 12 was acidified with 1 equivalent of concentrated hydrochloric acid in water and stirred. The solution was then vacuum filtered and vacuum dried to yield the free acid.

Workup

  1. filtrationvacuum filtered
  2. customvacuum dried
  3. customto yield the free acid

Sources & evidence

ORD record
ord-9093e07bbf5b423f97c42bf0a66dd9ec
Source dataset
uspto-grants-2014_02
Patent number
US08658695B2

Reaction notes

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