反应详情

A solution of tert-butyl N-[(1S)-2-hydroxy-2-methyl-cyclopentyl]carbamate (mixture of cis and trans diastereomers) (6.66 g, 30.9 mmol), 4 M HCl in dioxane (46.4 mL, 185.6 mmol), and dichloromethane (62 mL) is stirred at room temperature for 1 h. The reaction is concentrated in vacuo, and then redissolved in MeOH and reconcentrated to give the title compound as a brown oil (5.09 g). LC-ES/MS m/z 116 (M+1).

1. concentrationThe reaction is concentrated in vacuo
2. dissolutionredissolved in MeOH