1,1-Dimethylethyl 4-fluoro-1,4'-bipiperidine-1'-carboxylate → HCID 53418783, compound

HRID 245140Notes

Reaction equation

HRID 245140 reaction equation
[F:1][CH:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[F:1][CH:2]1[CH2:3][CH2:4][N:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 534190271,1-Dimethylethyl 4-fluoro-1,4'-bipiperidine-1'-carboxylate

Product 1

HCID 53418783HCID 53418783, compoundYield 133.8%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A mixture of 1,1-dimethylethyl 4-fluoro-1,4′-bipiperidine-1′-carboxylate (0.300 g, 1.047 mmol) in 10 mL of 4N HCl/dioxane was stirred at room temperature for 18 h. The solid material was collected by filtration, washed with ether and dried to afford 4-fluoro-1,4′-bipiperidine (0.261 g, 96% yield). MS (m/z) 187 (M+H+).

Workup

  1. filtrationThe solid material was collected by filtration
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-3c4dabb567a2496a912fa1b4febc2a62
Source dataset
uspto-grants-2014_02
Patent number
US08658636B2

Reaction notes

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