反应详情

A mixture of 1,1-dimethylethyl 4-fluoro-1,4′-bipiperidine-1′-carboxylate (0.300 g, 1.047 mmol) in 10 mL of 4N HCl/dioxane was stirred at room temperature for 18 h. The solid material was collected by filtration, washed with ether and dried to afford 4-fluoro-1,4′-bipiperidine (0.261 g, 96% yield). MS (m/z) 187 (M+H+).

1. filtrationThe solid material was collected by filtration
2. washwashed with ether
3. customdried