HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl 4-fluoro-1,4'-bipiperidine-1'-carboxylate → HCID 53418783, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl 4-fluoro-1,4'-bipiperidine-1'-carboxylate | HCID 53419027 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | HCID 53418783 | HCID 53418783 | 133.8% |
Reaction Steps
A mixture of 1,1-dimethylethyl 4-fluoro-1,4′-bipiperidine-1′-carboxylate (0.300 g, 1.047 mmol) in 10 mL of 4N HCl/dioxane was stirred at room temperature for 18 h. The solid material was collected by filtration, washed with ether and dried to afford 4-fluoro-1,4′-bipiperidine (0.261 g, 96% yield). MS (m/z) 187 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658636B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-3c4dabb567a2496a912fa1b4febc2a62 |
| Source note | uspto-grants-2014_02 |