HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dibenzylamine → (S)-1-chloro-3-(dibenzylamino)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dibenzylamine | HCID 7656 | — |
| Reactant | (+)-Epichlorohydrin | HCID 149428 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-1-chloro-3-(dibenzylamino)propan-2-ol | HCID 49765557 | 94.9% |
Reaction Steps
Dibenzylamine (39.4 g, 0.20 mol) was added to 100 mL of methylene dichloride and stirred for 30 minutes. (S)-epichlorohydrin (21 g, 0.23 mol) was then added. The mixture was stirred at room temperature (25° C.) for 20 hours. Filtered, and the solvent was evaporated to provide 55 g of colorless oil in 93% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658789B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-cc1d1a70c1a9486b80c4e501192898b9 |
| Source note | uspto-grants-2014_02 |