Potassium Hydroxide → 2-Butyl-5-methanesulfonamido-benzofuran calcium salt

HRID 245341Notes

Reaction equation

HRID 245341 reaction equation
[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4].[OH-].[K+].[Cl-].[Ca+2:22].[Cl-]>O>[Ca:22].[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 5284359Calcium ChlorideHCID 9878493N-(2-Butyl-1-benzofuran-5-yl)methanesulfonamide

Product 1

HCID 673223392-Butyl-5-methanesulfonamido-benzofuran calcium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2.0 g 2-butyl-5-methanesulfonamido-benzofuran II was added to the solution of 0.5 g 85% potassium hydroxide in 20 ml water. The reaction mixture was stirred for 30 minutes. To the obtained solution 0.89 g calcium chloride dissolved in 5 ml water was added in 10 minutes, the resulting suspension was stirred at 20-25° C. for 1 hour and then at 5° C. for 2 hours. The product was filtered off and dried.

Workup

  1. additionwas added in 10 minutes
  2. stirringthe resulting suspension was stirred at 20-25° C. for 1 hour
  3. waitat 5° C. for 2 hours
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-9db2ad9d36bc4552a652688118b84267
Source dataset
uspto-grants-2014_02
Patent number
US08658809B2

Reaction notes

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