2,6-Dimethylmorpholine, cis- → 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid

HRID 245372Notes

Reaction equation

HRID 245372 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6].[CH3:13][C@H:14]1[O:19][C@@H:18]([CH3:20])[CH2:17][NH:16][CH2:15]1>>[Cl:1][C:2]1[C:3]([N:16]2[CH2:15][C@H:14]([CH3:13])[O:19][C@H:18]([CH3:20])[CH2:17]2)=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 27735323-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 673589363-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid

Procedure

Starting materials: 3-chloro-2,4-difluorobenzoic acid and cis-2,6-dimethylmorpholine.

Sources & evidence

ORD record
ord-67e4c68322944f83a0475ec2f72729a3
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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