4,4-Difluoropiperidine → HCID 67358088, compound

HRID 245488Notes

Reaction equation

HRID 245488 reaction equation
[Si]([O:18][CH2:19][C:20]1[C:21]([N:35]2[CH2:40][C@H:39]([CH3:41])[O:38][C@H:37]([CH3:42])[CH2:36]2)=[C:22]([F:34])[C:23]2[O:27][N:26]=[C:25]([C:28](OCC)=[O:29])[C:24]=2[CH:33]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[F:43][C:44]1([F:50])[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]1>>[F:43][C:44]1([F:50])[CH2:49][CH2:48][N:47]([C:28]([C:25]2[C:24]3[CH:33]=[C:20]([CH2:19][OH:18])[C:21]([N:35]4[CH2:36][C@H:37]([CH3:42])[O:38][C@H:39]([CH3:41])[CH2:40]4)=[C:22]([F:34])[C:23]=3[O:27][N:26]=2)=[O:29])[CH2:46][CH2:45]1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 67357675ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate2×

Product 1

HCID 67358088HCID 67358088, compound

Procedure

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and 4,4-difluoropiperidine

Sources & evidence

ORD record
ord-619d5cce598442a89f3a75da43e669c4
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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