rel-(3R,5S)-3,5-Dimethylpiperidine → 6-((3S,5R)-3,5-dimethylpiperidin-1-yl)-7-fluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde

HRID 245535Notes

Reaction equation

HRID 245535 reaction equation
F[C:2]1[C:11]([CH:12]=[O:13])=[CH:10][C:5]2[C:6]([CH3:9])=[N:7][O:8][C:4]=2[C:3]=1[F:14].[CH3:15][C@H:16]1[CH2:21][C@@H:20]([CH3:22])[CH2:19][NH:18][CH2:17]1>>[CH3:15][C@H:16]1[CH2:21][C@@H:20]([CH3:22])[CH2:19][N:18]([C:2]2[C:11]([CH:12]=[O:13])=[CH:10][C:5]3[C:6]([CH3:9])=[N:7][O:8][C:4]=3[C:3]=2[F:14])[CH2:17]1

Participants

3

Reactant 2

HCID 641101rel-(3R,5S)-3,5-DimethylpiperidineHCID 86658113HCID 86658113, compound2×

Product 1

HCID 866581266-((3S,5R)-3,5-dimethylpiperidin-1-yl)-7-fluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde

Procedure

Starting materials: 6,7-difluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde (Intermediate 374) and (3S,5R)-3,5-dimethylpiperidine (HCl Salt).

Sources & evidence

ORD record
ord-1aaee412b0e64996a9cefa25369b2011
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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