Benzyl Bromide → HCID 86658134, compound

HRID 245542Notes

Reaction equation

HRID 245542 reaction equation
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C@H:10]1[O:15][C@@H:14]([CH3:16])[CH2:13][N:12]([C:17]2[C:26]([CH:27]=[O:28])=[CH:25][C:20]3[C:21]([OH:24])=[N:22][O:23][C:19]=3[C:18]=2[F:29])[CH2:11]1>>[CH2:1]([O:24][C:21]1[C:20]2[CH:25]=[C:26]([CH:27]=[O:28])[C:17]([N:12]3[CH2:13][C@H:14]([CH3:16])[O:15][C@H:10]([CH3:9])[CH2:11]3)=[C:18]([F:29])[C:19]=2[O:23][N:22]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 178461507HCID 178461507, compound2×

Product 1

HCID 86658134HCID 86658134, compound

Procedure

Benzyl bromide and 6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-fluoro-3-hydroxy-1,2-benzisoxazole-5-carbaldehyde (Intermediate 556) were reacted using a method similar to the one described for the synthesis of Intermediate 557, providing the title product, along with a by-product, 2-benzyl-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-fluoro-3-oxo-2,3-dihydro-1,2-benzoxazole-5-carbaldehyde. The mixture was used in the next step with out further purification.

Sources & evidence

ORD record
ord-aa1e0e7a61b74bc6b51f7af339ce8143
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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