Dimethylamine → HCID 67431681, compound

HRID 245573Notes

Reaction equation

HRID 245573 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:12]3[CH:13]=[C:14]4[C:27](=[C:28]([F:29])[C:11]=3[O:10][N:9]=2)[N:26]2[CH2:30][C@@H:31]([CH3:35])[O:32][C@@H:33]([CH3:34])[C@@H:25]2[C:16]2([C:21](=[O:22])[NH:20][C:19](=[O:23])[NH:18][C:17]2=[O:24])[CH2:15]4)[CH:5]=[N:4][CH:3]=1.[CH3:36][NH:37][CH3:38]>C1COCC1>[CH3:36][N:37]([CH3:38])[C:2]1[N:7]=[C:6]([C:8]2[C:12]3[CH:13]=[C:14]4[C:27](=[C:28]([F:29])[C:11]=3[O:10][N:9]=2)[N:26]2[CH2:30][C@@H:31]([CH3:35])[O:32][C@@H:33]([CH3:34])[C@@H:25]2[C:16]2([C:21](=[O:22])[NH:20][C:19](=[O:23])[NH:18][C:17]2=[O:24])[CH2:15]4)[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 87398665HCID 87398665, compound

Product 1

HCID 67431681HCID 67431681, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Starting materials: (2R,4S,4aS)-rel-8-(6-chloropyrazin-2-yl)-11-fluoro-2,4-dimethyl-2,4,4a,6-tetrahydro-1H,1′H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidine]-2′,4′,6′(3′H)-trione (Example 79) and 2N dimethylamine in THF.

Sources & evidence

ORD record
ord-458ae8906ca547e99763a5f2818557ef
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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