HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245665Generated: October 30, 2026
Methane → 2-(4-Isocyanato-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/245665
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 17750207 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Isocyanato-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 86674658 | 101.1% |
Reaction Steps
To 4-amino-3-methoxyphenylboronic acid pinacol ester (24.08 mmol, 6 g) and charcoal (0.29 g) in ethyl acetate (50 ml), was added trichloromethyl chloroformate (48.2 mmol, 5.81 mL) and the mixture was stirred at 70° C. for two hours. After cooling to room temperature the solids were removed by filtration and the filtrate concentrated in vacuo to give 6.7 g of 2-(4-isocyanato-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08658794B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-5292b91e4fc74c739fc47896a6e775e9 |
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| Source note | uspto-grants-2014_02 |
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