反应详情

To 8-methyl-3-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)imidazo[1,5-a]pyrazine (2.086 mmol, 654 mg) in N,N-dimethylformamide (10 mL) was added N-bromosuccinimide (2.295 mmol, 408 mg) and the mixture was stirred at room temperature for one hour. The reaction mixture was evaporated to dryness. The residue was dissolved in dichloromethane/methanol 9/1 (100 mL) and this solution was washed with a mixture of water (2 ml), of saturated aqueous sodium hydrogencarbonate (2 mL) and a few drops of 2 N sodium hydroxide, the organic layer dried (sodium sulfate) and evaporated to dryness to yield crude 1-bromo-8-methyl-3-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)imidazo[1,5-a]pyrazine (1.04 g)

1. customThe reaction mixture was evaporated to dryness
2. dissolutionThe residue was dissolved in dichloromethane/methanol 9/1 (100 mL)
3. washthis solution was washed with a mixture of water (2 ml), of saturated aqueous sodium hydrogencarbonate (2 mL) and a few drops of 2 N sodium hydroxide
4. dry with materialthe organic layer dried (sodium sulfate)
5. customevaporated to dryness