Morpholine → N-((3-chloropyrazin-2-yl)methyl)-4-morpholinocyclohexanecarboxamide

HRID 245680Notes

Reaction equation

HRID 245680 reaction equation
[Cl:1][C:2]1[C:3]([CH2:8][NH:9][C:10]([CH:12]2[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]2)=[O:11])=[N:4][CH:5]=[CH:6][N:7]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[C:3]([CH2:8][NH:9][C:10]([CH:12]2[CH2:17][CH2:16][CH:15]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[CH2:14][CH2:13]2)=[O:11])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 86674630N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexanecarboxamide

Product 1

HCID 86674644N-((3-chloropyrazin-2-yl)methyl)-4-morpholinocyclohexanecarboxamide

Procedure

According to the procedure described in example 7 step 7a N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexanecarboxamide (1 g) and morpholine (0.44 mL) gave after work-up N-((3-chloropyrazin-2-yl)methyl)-4-morpholinocyclohexanecarboxamide (1.28 g). This crude product was used in the next step without further purification.

Sources & evidence

ORD record
ord-a99c7b8e5467417da344e96eac4442dc
Source dataset
uspto-grants-2014_02
Patent number
US08658794B2

Reaction notes

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