Hydrochloric Acid → HCID 67365154, compound

HRID 245702Notes

Reaction equation

HRID 245702 reaction equation
[CH3:1][C:2]1[C:3]2[N:4]([C:8]([N:11]3[CH2:16][CH2:15][N:14](C(OCC4C=CC=CC=4)=O)[CH2:13][CH2:12]3)=[N:9][CH:10]=2)[CH:5]=[CH:6][N:7]=1.[ClH:27]>O>[ClH:27].[CH3:1][C:2]1[C:3]2[N:4]([C:8]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[N:9][CH:10]=2)[CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67362824HCID 67362824, compound

Product 1

HCID 67365154HCID 67365154, compoundYield 91.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Benzyl 4-(8-methylimidazo[1,5-a]pyrazin-3-yl)piperazine-1-carboxylate (486 mg) in 37% hydrochloric acid (97 mmol, 8 ml) was stirred at room temperature for two hours. Then water (16 ml) was added and the mixture washed twice with diethyl ether. The aqueous layer was concentrated in vacuo and co-evaporated with toluene and ethanol to give 8-methyl-3-(piperazin-1-yl)imidazo[1,5-a]pyrazine hydrochloride (322 mg).

Workup

  1. washthe mixture washed twice with diethyl ether
  2. concentrationThe aqueous layer was concentrated in vacuo and co-evaporated with toluene and ethanol

Sources & evidence

ORD record
ord-1113a25b592b40bc8d26d7f43860b4fe
Source dataset
uspto-grants-2014_02
Patent number
US08658794B2

Reaction notes

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