反应详情

Benzyl((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methylcarbamate (1.5 g, 3.28 mmol) was dissolved in hydrobromic acid 33% in acetic acid (15 mL, 3.28 mmol) and the resulting mixture was stirred at room temperature. After eight hours the reaction mixture was concentrated in vacuo and dried in a vacuum oven (40° C.) for three days to yield ((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methanamine hydrobromide (1.77 g).

1. concentrationAfter eight hours the reaction mixture was concentrated in vacuo
2. customdried in a vacuum oven (40° C.) for three days