HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178502113, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 178432907 | HCID 178432907 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178502113 | HCID 178502113 | 54.8% |
Reaction Steps
To ((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methanamine (0.464 mmol, 150 mg) in dichloromethane (5 ml) at 0° C. were added triethylamine (0.464 mmol, 64.7 μl) and methyl carbonochloridate (0.505 mmol, 39 μl). After stirring at room temperature for one hour water was added. The organic layer separated, dried (Na2SO4) and concentrated in vacuo to give methyl((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methylcarbamate (97 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658794B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-5361bae56cb24c0cb4083e6fbfc498ac |
| Source note | uspto-grants-2014_02 |