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HRID245761

反应详情

EQUATION

反应方程式

HRID 245761 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：COC(=O)Cl
HCID6586

Methyl chlorocarbonate

C2H3ClO2

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Cc1nccn2c1c(Br)nc2[C@H]1CC[C@H](CN)CC1
HCID178432907

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)NC[C@H]1CC[C@H](c2nc(Br)c3c(C)nccn32)CC1
HCID178502113

未命名化合物

收率 54.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To ((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methanamine (0.464 mmol, 150 mg) in dichloromethane (5 ml) at 0° C. were added triethylamine (0.464 mmol, 64.7 μl) and methyl carbonochloridate (0.505 mmol, 39 μl). After stirring at room temperature for one hour water was added. The organic layer separated, dried (Na2SO4) and concentrated in vacuo to give methyl((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methylcarbamate (97 mg).

WORKUP

后处理

  1. additionwas added
  2. customThe organic layer separated
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo