Hydrochloric Acid → 1-(1,2-Oxazol-3-yl)ethan-1-amine hydrochloride

HRID 245905Notes

Reaction equation

HRID 245905 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([NH:8]S(C(C)(C)C)=O)[CH3:7])=[N:2]1.[ClH:15]>CO>[ClH:15].[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([NH2:8])[CH3:7])=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71288179N-[1-(3-Isoxazolyl)ethyl]-2-methyl-2-propanesulfinamide

Product 1

HCID 552533511-(1,2-Oxazol-3-yl)ethan-1-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a round-bottomed flask, 2-methyl-propane-2-sulfinic acid (1-isoxazol-3-yl-ethyl)-amide (652 mg, 2.71 mmol) was dissolved in methanol (5 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 1.4 ml, 5.6 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 15 min then concentrated to give 1-isoxazol-3-yl-ethylamine hydrochloride as an off-white solid which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-d28636f012234258acc27013aad70633
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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