Trifluoroacetic acid → (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

HRID 245910Notes

Reaction equation

HRID 245910 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH3:13])[C:9]([F:12])([F:11])[CH3:10])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[F:11][C:9]([F:12])([CH3:10])[C@H:8]([NH2:7])[CH3:13]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86677920((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester

Product 1

HCID 86677918(R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a round-bottomed flask, ((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester (148 mg, 0.71 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.6 ml, 20.8 mmol) was slowly added. The reaction mixture was stirred at room temperature for 1.5 h then concentrated to give (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate as a light brown oil which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-7543787c2f79473aa5d98a0a2c337a2a
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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