Trifluoroacetic acid → HCID 86677924, compound

HRID 245928Notes

Reaction equation

HRID 245928 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10](=[O:15])[NH:11][CH2:12][CH2:13][OH:14])[CH3:9])(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C@H:8]([CH3:9])[C:10]([NH:11][CH2:12][CH2:13][OH:14])=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86677923[(R)-1-(2-hydroxy-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 86677924HCID 86677924, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a round-bottomed flask, [(R)-1-(2-hydroxy-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (180 mg, 0.78 mmol) was dissolved in dichloromethane (5 ml) and trifluoroacetic acid (1.8 ml, 23.4 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2 h then concentrated to afford (R)-2-amino-N-(2-hydroxy-ethyl)-propionamide trifluoroacetate as a light yellow oil which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-a5a7c0e8d56c4b7c9bf4a465add0e46f
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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