Ethylenediamine → HCID 178464935, compound

HRID 245996Notes

Reaction equation

HRID 245996 reaction equation
[OH:1][C@@H:2]1[CH2:5][C@H:4]([CH:6]([NH:8][C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[C:17]([C:20]4[C:28]5[C:23](=[CH:24][C:25]([F:29])=[CH:26][CH:27]=5)[N:22]([CH3:30])[N:21]=4)[N:18]=3)[N:13](COCC[Si](C)(C)C)[CH:12]=2)=[O:10])[CH3:7])[CH2:3]1.C(O)(C(F)(F)F)=O.C(N)CN>C(Cl)Cl>[OH:1][C@@H:2]1[CH2:3][C@H:4]([CH:6]([NH:8][C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[C:17]([C:20]4[C:28]5[C:23](=[CH:24][C:25]([F:29])=[CH:26][CH:27]=5)[N:22]([CH3:30])[N:21]=4)[N:18]=3)[NH:13][CH:12]=2)=[O:10])[CH3:7])[CH2:5]1

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 6422Trifluoroacetic acidHCID 178464928HCID 178464928, compound

Product 1

HCID 178464935HCID 178464935, compoundYield 62.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(cis-3-hydroxy-cyclobutyl)-ethyl]-amide (60 mg, 0.11 mmol) in CH2Cl2 (2 mL) was added TFA (1 mL, 13.0 mmol). The bright yellow-orange reaction mixture was stirred at room temperature for 3 h then concentrated. The residue was redissolved in CH2Cl2 (2 mL) and ethylene diamine (0.4 mL, 6.0 mmol) was added. The reaction mixture was stirred at room temperature for 1 h then quenched with water and diluted with CH2Cl2. A very fine precipitate formed which was collected via filtration. This solid was taken up in MeOH/CH2Cl2 (200 mL) and filtered again, rinsing with MeOH/CH2Cl2. The filtrate was concentrated and triturated with EtOAc/MeOH to afford 28 mg (62%) of 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(cis-3-hydroxy-cyclobutyl)-ethyl]-amide as a light yellow solid. MS: (M+H)+=409; 1H NMR (DMSO-d6,300 MHz): δ (ppm) 9.08 (s, 1H), 8.37-8.48 (m, 2H), 7.96 (d, J=8.7 Hz, 1H), 7.70 (dd, J=9.8, 1.9 Hz, 1H), 7.18 (td, J=9.1, 2.3 Hz, 1H), 4.92 (br. s., 1H), 4.14 (s, 3H), 4.04-4.13 (m, 1H), 3.87 (br. s., 1H), 2.14-2.34 (m, 2H), 1.78-1.93 (m, 1H), 1.58 (quin, J=9.8 Hz, 2H), 1.19 (d, J=6.8 Hz, 3H).

Workup

  1. concentrationthen concentrated
  2. dissolutionThe residue was redissolved in CH2Cl2 (2 mL)
  3. stirringThe reaction mixture was stirred at room temperature for 1 h
  4. customthen quenched with water
  5. additiondiluted with CH2Cl2
  6. customA very fine precipitate formed which
  7. filtrationwas collected via filtration
  8. filtrationfiltered again
  9. washrinsing with MeOH/CH2Cl2
  10. concentrationThe filtrate was concentrated
  11. customtriturated with EtOAc/MeOH

Sources & evidence

ORD record
ord-86a6a10ffc754dcfb622710d222c7957
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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