反应详情

10 ml of ethyl acetate was added to a mixture of 164 mg (0.350 mmol) of 6-(2-azidoethoxymethyl)-4-(3-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3-phenylpropyl)amide and a catalytic amount of 10% palladium/carbon, and they were stirred at room temperature in hydrogen atmosphere under normal pressure for 24 hours. The catalyst was filtered out, and the filtrate was concentrated under reduced pressure. The residue was purified by the basic silica gel chromatography (dichloromethane/methanol=100/1 to 20/1) to obtain the title compound.

1. filtrationThe catalyst was filtered out
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by the basic silica gel chromatography (dichloromethane/methanol=100/1 to 20/1)