Trifluoroacetic acid → (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

HRID 246121Notes

Reaction equation

HRID 246121 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH3:15])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[CH3:15][C@@H:8]([NH2:7])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71279609((R)-1-methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester

Product 1

HCID 71279935(R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

((R)-1-Methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester (49 mg, 0.22 mmol) was dissolved in dichloromethane (2.4 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 2 h then evaporated and dried under high vacuum to afford (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate which was used without further purification.

Workup

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-4d94d1181e9045979f536c89b3a589b0
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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