Hydrochloric Acid → [6-(3-chlorophenyl)-5-(3,3-diphenylpropyl carbamoyl)-4-methyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-yl]acetic acid

Participants

Reaction Steps

59.7 mg (0.109 mmol) of ethyl [6-(3-chlorophenyl)-5-(3,3-diphenylpropylcarbamoyl)-4-methyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-yl]acetate was dissolved in 10 ml of methanol. 0.219 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution at room temperature, and they were stirred for 12 hours. 1 N hydrochloric acid was added to the reaction mixture. Methanol was evaporated under reduced pressure. Water was added to the residue, and precipitates thus formed were taken by the filtration, then washed with hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

Provenance & Evidence