Ethylenediamine → HCID 71288354, compound

HRID 246205Notes

Reaction equation

HRID 246205 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]([NH:9][C:10]([C:12]1[C:20]2[C:15](=[N:16][CH:17]=[C:18]([C:21]3[C:29]4[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=4)[N:23]([CH3:31])[N:22]=3)[N:19]=2)[N:14](COCC[Si](C)(C)C)[CH:13]=1)=[O:11])[CH3:8].C(Cl)Cl.C(N)CN>C(O)(C(F)(F)F)=O>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]([NH:9][C:10]([C:12]1[C:20]2[C:15](=[N:16][CH:17]=[C:18]([C:21]3[C:29]4[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=4)[N:23]([CH3:31])[N:22]=3)[N:19]=2)[NH:14][CH:13]=1)=[O:11])[CH3:8]

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 6344DichloromethaneHCID 71286089HCID 71286089, compound

Product 1

HCID 71288354HCID 71288354, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(1-methyl-1H-imidazol-2-yl)-ethyl]-amide (300 mg, 0.531 mol) was dissolved in a 4:6 solution of TFA:DCM (142 mL). After stirring at room temperature overnight, the volatiles were removed under reduced pressure. The crude material was then dissolved in dichloromethane and treated with ethylenediamine (319 mg, 5.31 mmol). After stirring at room temperature overnight, the precipitate was collected by filtration to afford 100 mg (43%) of 2-(6-chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(1-methyl-1H-imidazol-2-yl)-ethyl]-amide as a yellow solid. MS: (M+H)+=435; 1H NMR (300 MHz, DMSO-d6) δ ppm 9.12 (s, 1H) 8.50-8.63 (m, 2H) 8.49-8.50 (m, 1H) 7.96 (d, J=1.51 Hz, 1H) 7.29 (dd, J=8.69, 1.51 Hz, 1H) 7.09 (s, 1H) 6.85 (s, 1H) 5.40-5.68 (m, 1H) 4.15 (s, 3H) 3.63-3.77 (m, 3H) 1.61 (d, J=6.80 Hz, 3H).

Workup

  1. customthe volatiles were removed under reduced pressure
  2. dissolutionThe crude material was then dissolved in dichloromethane
  3. stirringAfter stirring at room temperature overnight
  4. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-a9246a2368f748eea50bfe1fd2cd4c87
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

Loading…