Hydrochloric Acid → (S)-1-(3-(trifluoromethoxy)phenyl)ethanamine hydrochloride

Participants

Reaction Steps

In a 25 ml round-bottomed flask, (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(3-trifluoromethoxy-phenyl)-ethyl]-amide (157 mg, 0.51 mmol) was dissolved in methanol (1 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 0.26 ml, 1.04 mmol) was added dropwise. The reaction was stirred at room temperature for 20 min then concentrated to give (S)-1-(3-trifluoromethoxy-phenyl)-ethylamine hydrochloride as an off-white waxy solid which was used without further purification.

Provenance & Evidence