Hydrochloric Acid → (S)-1-(3-(trifluoromethoxy)phenyl)ethanamine hydrochloride

HRID 246277Notes

Reaction equation

HRID 246277 reaction equation
[F:1][C:2]([F:20])([F:19])[O:3][C:4]1[CH:5]=[C:6]([C@@H:10]([NH:12][S@](C(C)(C)C)=O)[CH3:11])[CH:7]=[CH:8][CH:9]=1.[ClH:21]>CO>[ClH:21].[F:1][C:2]([F:19])([F:20])[O:3][C:4]1[CH:5]=[C:6]([C@@H:10]([NH2:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71288451HCID 71288451, compound

Product 1

HCID 71280121(S)-1-(3-(trifluoromethoxy)phenyl)ethanamine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 25 ml round-bottomed flask, (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(3-trifluoromethoxy-phenyl)-ethyl]-amide (157 mg, 0.51 mmol) was dissolved in methanol (1 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 0.26 ml, 1.04 mmol) was added dropwise. The reaction was stirred at room temperature for 20 min then concentrated to give (S)-1-(3-trifluoromethoxy-phenyl)-ethylamine hydrochloride as an off-white waxy solid which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-a96c15c8bb244d1c8327c949204683c4
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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