Trifluoroacetic acid → HCID 71280181, compound

HRID 246280Notes

Reaction equation

HRID 246280 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 712805461426423-60-0

Product 1

HCID 71280181HCID 71280181, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a 25 ml round-bottomed flask, [1-(1-hydroxy-1-methyl-ethyl)-cyclobutyl]-carbamic acid tert-butyl ester (150 mg, 0.65 mmol) was dissolved in dichloromethane (3.8 ml) and trifluoroacetic acid (1.5 ml, 19.5 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2.5 h then concentrated to give 2-(1-amino-cyclobutyl)-propan-2-ol trifluoroacetate as a light brown oil which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-0f8391747d01459a998776a704523355
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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