HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dimethylamino-6-methoxyphenylboronic acid → N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dimethylamino-6-methoxyphenylboronic acid | HCID 4374258 | — |
| Reactant | N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester | HCID 54284267 | — |
| Product | N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester | HCID 54467033 | — |
Reaction Steps
2-Methoxy-6-(N,N-dimethylamino)benzene boronic acid was coupled with N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester to give N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester. The preparation of the boronic acid and the coupling reaction was carried out in a similar manner as described in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855843B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-96c7043f398846339ce0e3602e9d5816 |
| Source note | uspto-grants-2005_02 |