Ethylenediamine → HCID 71280086, compound

HRID 246462Notes

Reaction equation

HRID 246462 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:12]3[N:17]=[C:16]4[C:18]([C:29]([NH:31][CH2:32][CH:33]5[CH2:35][CH2:34]5)=[O:30])=[CH:19][N:20](COCC[Si](C)(C)C)[C:15]4=[N:14][CH:13]=3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O.C(N)CN>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:12]3[N:17]=[C:16]4[C:18]([C:29]([NH:31][CH2:32][CH:33]5[CH2:34][CH2:35]5)=[O:30])=[CH:19][NH:20][C:15]4=[N:14][CH:13]=3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 6422Trifluoroacetic acidHCID 71280490HCID 71280490, compound

Product 1

HCID 71280086HCID 71280086, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(cyclopropylmethyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (0.049 g, 0.096 mmol) in dichloromethane (5 mL) was added TFA (0.55 g, 0.36 mL, 4.78 mmol) at 20° C. After 18 h, the mixture was concentrated in vacuo. The residue was diluted with dichloromethane and concentrated again. The residue was then suspended in dichloromethane (5 mL) and ethylenediamine (0.29 g, 0.32 mL, 4.78 mmol) was added. The mixture was stirred for 18 h, then concentrated in vacuo. The residue was triturated with water and collected by filtration, washed with water and dried in a vacuum oven to give 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(cyclopropylmethyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (0.034 g, 0.089 mmol, 93%) as a yellow solid. MS (M+H)+=381; 1H NMR (DMSO-d6) δ: 9.10 (s, 1H), 8.47 (d, J=8.7 Hz, 2H), 8.44 (s, 1H), 8.21 (t, J=5.4 Hz, 1H), 8.00 (d, J=1.3 Hz, 2H), 7.31 (dd, J=8.6, 1.8 Hz, 2H), 4.18 (s, 3H), 3.33-3.40 (m, 2H), 1.04-1.28 (m, 1H), 0.48-0.65 (m, 2H), 0.27-0.41 (m, 2H).

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. additionThe residue was diluted with dichloromethane
  3. concentrationconcentrated again
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with water
  6. filtrationcollected by filtration
  7. washwashed with water
  8. customdried in a vacuum oven

Sources & evidence

ORD record
ord-a94f47d0da0c4d7895069f763637bc09
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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