Cesium carbonate → HCID 71280054, compound

HRID 246502Notes

Reaction equation

HRID 246502 reaction equation
[C:1]([NH:5][C:6]([C:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH:27]([F:29])[F:28])[CH:24]=4)[NH:19][N:18]=3)[N:15]=2)[N:10]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:39][CH2:40][C:41]([N:43]([CH3:45])[CH3:44])=[O:42].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[C:1]([NH:5][C:6]([C:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH:27]([F:28])[F:29])[CH:24]=4)[N:19]([CH2:39][CH2:40][C:41]([N:43]([CH3:45])[CH3:44])=[O:42])[N:18]=3)[N:15]=2)[N:10]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 32690663-chloro-N,N-dimethylpropanamideHCID 712795662-(5-difluoromethoxy-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide

Product 1

HCID 71280054HCID 71280054, compoundYield 59.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

N-tert-Butyl-2-(5-(difluoromethoxy)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (100 mg, 188 μmol), 3-chloro-N,N-dimethylpropanamide (25.6 mg, 188 μmol) and cesium carbonate (184 mg, 565 mmol) in dimethylformamide (2 mL) were heated in a microwave at 150° C. for 30 min. The mixture was cooled, partitioned between ethyl acetate and water, washed with water 3 times, dried and concentrated in vacuo. Purification by chromatography (silica, 24 g Analogix column, 0-100% ethyl acetate in hexanes) gave N-tert-butyl-2-(5-(difluoromethoxy)-1-(3-(dimethylamino)-3-oxopropyl)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (70 mg, 59%) as an off-white solid. MS (M+H)+=630; 1H NMR (CDCl3) δ: 9.19 (s, 1H), 8.41 (s, 1H), 8.25 (d, J=1.9 Hz, 1H), 8.08 (s, 1H), 7.67 (d, J=8.7 Hz, 1H), 7.31-7.37 (m, 1H), 6.22-6.78 (m, 1H), 5.72 (s, 2H), 4.79-4.88 (m, 2H), 3.53-3.63 (m, 2H), 3.11 (t, J=6.7 Hz, 2H), 2.95 (d, J=9.2 Hz, 6H), 1.61 (s, 9H), 0.87-1.01 (m, 2H), −0.03 (s, 9H).

Workup

  1. temperatureThe mixture was cooled
  2. custompartitioned between ethyl acetate and water
  3. washwashed with water 3 times
  4. customdried
  5. concentrationconcentrated in vacuo
  6. customPurification by chromatography (silica, 24 g Analogix column, 0-100% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-41e3cee5199f457a9f76d40116c38d56
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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