HRID246507

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CN(C(=O)OC(C)(C)C)C4)c4ccc(OC(F)F)cc34)nc12

HCID71280303

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CNC4)c4ccc(OC(F)F)cc34)nc12

HCID71279937

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6409

2,2,2-Trifluoroethanol

C2H3F3O

PROCEDURE

实验过程

A stirred solution of tert-butyl 3-((3-(7-(tert-butylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-5-(difluoromethoxy)-1H-indazol-1-yl)methyl)azetidine-1-carboxylate (180 mg, 257 μmol) in 2,2,2-trifluoroethanol (2 mL) was heated in a microwave at 150° C. for 6 h then cooled, concentrated and used in the next reaction without purification.

WORKUP

后处理

temperaturethen cooled
concentrationconcentrated
customused in the next reaction without purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45183f7897a143d5a6260560e025d265
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08658646B2
来源说明: uspto-grants-2014_02

反应 SMILES

[C:1]([NH:5][C:6]([C:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH:27]([F:29])[F:28])[CH:24]=4)[N:19]([CH2:30][CH:31]4[CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]4)[N:18]=3)[N:15]=2)[N:10]([CH2:42][O:43][CH2:44][CH2:45][Si:46]([CH3:49])([CH3:48])[CH3:47])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>FC(F)(F)CO>[NH:33]1[CH2:34][CH:31]([CH2:30][N:19]2[C:20]3[C:25](=[CH:24][C:23]([O:26][CH:27]([F:29])[F:28])=[CH:22][CH:21]=3)[C:17]([C:14]3[N:15]=[C:16]4[C:8]([C:6]([NH:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])=[CH:9][N:10]([CH2:42][O:43][CH2:44][CH2:45][Si:46]([CH3:49])([CH3:48])[CH3:47])[C:11]4=[N:12][CH:13]=3)=[N:18]2)[CH2:32]1