HRID246522

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3nc(C4CCN(C(=O)OC(C)(C)C)CC4)c4ccccc43)nc12

HCID71280186

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3nc(C4CCNCC4)c4ccccc43)nc12

HCID71280834

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6409

2,2,2-Trifluoroethanol

C2H3F3O

PROCEDURE

实验过程

A stirred solution of tert-butyl 4-(1-(7-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-1H-indazol-3-yl)piperidine-1-carboxylate (120 mg, 181 μmol) in 2,2,2-trifluoroethanol (2 mL) was heated in a microwave at 150° C. for 4 h. The mixture was concentrated in vacuo and used in the next step without purification.

WORKUP

后处理

concentrationThe mixture was concentrated in vacuo
customused in the next step without purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71b31651759c4cde94762d600ba64915
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08658646B2
来源说明: uspto-grants-2014_02

反应 SMILES

[OH:1][CH2:2][C:3]([NH:6][C:7]([C:9]1[C:17]2[C:12](=[N:13][CH:14]=[C:15]([N:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:20]([CH:27]4[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]4)=[N:19]3)[N:16]=2)[N:11]([CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:47])([CH3:46])[CH3:45])[CH:10]=1)=[O:8])([CH3:5])[CH3:4]>FC(F)(F)CO>[OH:1][CH2:2][C:3]([NH:6][C:7]([C:9]1[C:17]2[C:12](=[N:13][CH:14]=[C:15]([N:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:20]([CH:27]4[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]4)=[N:19]3)[N:16]=2)[N:11]([CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:46])([CH3:45])[CH3:47])[CH:10]=1)=[O:8])([CH3:5])[CH3:4]