反应详情

温度

100 °C

To a stirred solution of (S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate (200 mg, 716 μmol) in methanol (6 mL) was added sodium methoxide (77.4 mg, 1.43 mmol). The mixture was heated in microwave at 100° C. for 60 min. The mixture was concentrated in vacuo. The residue was dissolved in ethyl acetate, then washed saturated aqueous sodium carbonate, brine, then dried (sodium sulfate), filtered and concentrated in vacuo to give 2-((S)-1-tert-butoxycarbonylamino-ethyl)-3H-imidazole-4-carboxylic acid methyl ester (154 mg, 80%) as a yellow solid. This was used directly in the next step without further purification. LCMS, [M+H]=270.

1. concentrationThe mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in ethyl acetate
3. dry with materialwashed saturated aqueous sodium carbonate, brine, then dried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated in vacuo