HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86677998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-tert-Butyldimethylsilyloxy-1,1-dimethylethylamine | HCID 14806740 | — |
| Reactant | 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid | HCID 86677897 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86677998 | HCID 86677998 | — |
Reaction Steps
A mixture of 2-bromo-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (310 mg, 1.28 mmol), 1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-amine (390 mg, 1.92 mmol), EDCI (489 mg, 2.56 mmol) and DMAP (312 mg, 2.56 mmol) in 5 mL of DMF was stirred at room temperature for 16 hours. Then the mixture was poured into water and extracted with EtOAc (3×10 mL). The combined organic layers were washed with brine and dried over Na2SO4. After filtration and concentration, the residue was used in the next step without further treatment. MS: (M+H)+=427.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658646B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-16373a3cf1384e9ea068ab3c8c72a427 |
| Source note | uspto-grants-2014_02 |