反应详情

A mixture of 2-bromo-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (310 mg, 1.28 mmol), 1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-amine (390 mg, 1.92 mmol), EDCI (489 mg, 2.56 mmol) and DMAP (312 mg, 2.56 mmol) in 5 mL of DMF was stirred at room temperature for 16 hours. Then the mixture was poured into water and extracted with EtOAc (3×10 mL). The combined organic layers were washed with brine and dried over Na2SO4. After filtration and concentration, the residue was used in the next step without further treatment. MS: (M+H)+=427.1.

1. extractionextracted with EtOAc (3×10 mL)
2. washThe combined organic layers were washed with brine
3. dry with materialdried over Na2SO4
4. filtrationAfter filtration and concentration