反应详情

To a stirred solution of tert-butyl 5-(difluoromethoxy)-3-iodo-1H-indazole-1-carboxylate (410 mg, 1 mmol) in dichloromethane (10 mL) was added drop-wise trifluoroacetic acid (5 mL) at room temperature and the reaction mixture was stirred for 1 hour. The mixture was washed with NaHCO3 aqueous, and then organic was dried over Na2SO4. After filtration and concentration, 5-(difluoromethoxy)-3-iodo-1H-indazole (300 mg, 97%) was obtained as a white solid, used in the next step without further purification. MS: (M+H)+=311.

1. washThe mixture was washed with NaHCO3 aqueous
2. dry with materialorganic was dried over Na2SO4
3. filtrationAfter filtration and concentration