反应详情

A mixture of 2-bromo-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (250 mg, 1.03 mmol), 1-methylcyclopropanamine (150 mg, 2.2 mmol) and HATU (456 mg, 1.2 mmol) in 20 mL of dry THF was stirred for 4 hours. The reaction mixture was evaporated to dryness, the residue suspended in 20 mL of 0.5 N HCl, product extracted with ethyl acetate (3×50 mL), organics combined dried with sodium sulfate, filtered and concentrated. The residue was triturated with petroleum ether (2 mL) then decanted and dried to give 2-bromo-N-isopropyl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (125 mg, crude). LCMS: (M+H)+=285/287.

1. customThe reaction mixture was evaporated to dryness
2. extractionproduct extracted with ethyl acetate (3×50 mL)
3. dry with materialorganics combined dried with sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was triturated with petroleum ether (2 mL)
7. customthen decanted
8. customdried